Low-dose aspirin didn’t cut the risk of cardiovascular events but may have reduced CV mortality, a secondary end point, in the randomized but open-label trial conducted in Japan; clinical events were unexpectedly few, compromising the study’s statistical power.
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Low-dose aspirin didn’t cut the risk of cardiovascular events but may have reduced CV mortality, a secondary end point, in the randomized but open-label trial conducted in Japan; clinical events were unexpectedly few, compromising the study’s statistical power.
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The SEARCH trial showed no effect on major vascular events with either an intensive 80-mg dose of simvastatin compared with a 20-mg dose or with homocysteine lowering using folic acid and vitamin B12. But the statin data fit with other trials in the field, showing a “clear picture” emerging when it comes to the more-vs-less data on statins, say the UK investigators.
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The SEARCH trial showed no effect on major vascular events with either an intensive 80-mg dose of simvastatin compared with a 20-mg dose or with homocysteine lowering using folic acid and vitamin B12. But the statin data fit with other trials in the field, showing a “clear picture” emerging when it comes to the more-vs-less data on statins, say the UK investigators.
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Some back-of-the-envelope analyses suggest that the public-health implications of using statins in primary prevention, especially among individuals considered “healthy” by conventional definitions, is weighing heavily on the minds of some cardiologists. Heartwire spoke with many experts to get their take on the new JUPITER data.
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Some back-of-the-envelope analyses suggest that the public-health implications of using statins in primary prevention, especially among individuals considered “healthy” by conventional definitions, is weighing heavily on the minds of some cardiologists. Heartwire spoke with many experts to get their take on the new JUPITER data.
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The link between influenza vaccination and reduced pulmonary embolism or deep vein thrombosis was particularly marked in younger subjects, researchers say.
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The link between influenza vaccination and reduced pulmonary embolism or deep vein thrombosis was particularly marked in younger subjects, researchers say.
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There are a number of adjectives being thrown at the JUPITER study–groundbreaking and paradigm shifting are just two–but many experts believe the study, which showed significant cardiovascular risk reduction among healthy individuals with elevated CRP levels, is likely going to shake up the field of primary prevention.
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There are a number of adjectives being thrown at the JUPITER study–groundbreaking and paradigm shifting are just two–but many experts believe the study, which showed significant cardiovascular risk reduction among healthy individuals with elevated CRP levels, is likely going to shake up the field of primary prevention.
Heartwire

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